NRF · MSIT 연구과제 신청 전문 지원

수정 전

The aim of this research is to study the role of the gut microbiome in the development of type 2 diabetes. Machine learning approaches will also be explored, and the findings are expected to be useful for clinical practice.

수정 후

Aim 1 is to determine whether baseline gut microbiome composition predicts progression from prediabetes to type 2 diabetes over 24 months in a cohort of 600 adults. Success is defined in advance as a prediction model reaching an area under the ROC curve of at least 0.75 in a held-out validation set, benchmarked against fasting glucose alone.

수정 전

This research is of great importance and will make a significant contribution to the field. The results will be highly beneficial to society and will substantially advance our understanding of this important area of study.

수정 후

Prediabetes is currently managed by referring all patients to the same lifestyle programme, because no marker distinguishes those who will progress from those who will not. If the model reaches the accuracy threshold in Aim 1, clinics could direct intensive intervention to the highest-risk fifth of patients first. We will release the validated risk score and an open-source scoring tool in month 30, so a primary-care trial can begin without further discovery work.